InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S1PR3

Summary

InnateDB Protein

IDBP-75226.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1PR3

Protein Name

sphingosine-1-phosphate receptor 3

Synonyms

EDG-3; EDG3; LPB3; S1P3;

Species

Homo sapiens

Ensembl Protein

ENSP00000365006

InnateDB Gene

IDBG-239062 (S1PR3)

Protein Structure

UniProt Annotation

Function

Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269PubMed:10617617}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005178	integrin binding
GO:0008289	lipid binding
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0001816	cytokine production
GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0032651	regulation of interleukin-1 beta production
GO:1903141	negative regulation of establishment of endothelial barrier

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000987 EDG-1 sphingosine 1-phosphate receptor
IPR002230 Cannabinoid receptor family
IPR004061 Sphingosine 1-phosphate receptor
IPR004062 EDG-3 sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00642
PR00362
PR01523
PR01524

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99500