InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH8

Summary

InnateDB Protein

IDBP-752347.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH8

Protein Name

Synonyms

Nbla04261;

Species

Homo sapiens

Ensembl Protein

ENSP00000462701

InnateDB Gene

IDBG-34762 (CDH8)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007268	synaptic transmission
GO:0009409	response to cold
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0035249	synaptic transmission, glutamatergic
GO:0045216	cell-cell junction organization