InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESAM

Summary

InnateDB Protein

IDBP-75278.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESAM

Protein Name

endothelial cell adhesion molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278927

InnateDB Gene

IDBG-75276 (ESAM)

Protein Structure

UniProt Annotation

Function

Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250}.

Subcellular Localization

Cell junction, adherens junction {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in endothelial cells. {ECO:0000269PubMed:11279107}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0007596	blood coagulation
GO:0016337	single organismal cell-cell adhesion
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome