Version 5.4
Homo sapiens Protein: CLUAP1
Summary
InnateDB Protein IDBP-752781.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLUAP1
Protein Name
Synonyms CFAP22; FAP22;
Species Homo sapiens
Ensembl Protein ENSP00000460850
InnateDB Gene IDBG-12079 (CLUAP1)
Protein Structure
UniProt Annotation
Function Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cell projection, cilium.
Disease Associations
Tissue Specificity Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Highly expressed in colon cancer and osteosarcoma cell lines. {ECO:0000269PubMed:15480429, ECO:0000269PubMed:17203229}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030030 cell projection organization
Cellular Component
GO:0005634 nucleus
GO:0005929 cilium
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR019366 Clusterin-associated protein-1
PFAM PF00307
PF10234
PRINTS
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96AJ1
PhosphoSite PhosphoSite-Q96AJ1
TrEMBL I3L487
UniProt Splice Variant
Entrez Gene 23059
UniGene Hs.742198
RefSeq NP_055856
HUGO HGNC:19009
OMIM
CCDS CCDS32381
HPRD 10013
IMGT
EMBL AB014543 AB089691 AC004224 AC004494 AK023319 AK023359 BC017070
GenPept AAH17070 BAA31618 BAB14523 BAB14542 BAD44779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca