InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SP3

Summary

InnateDB Protein

IDBP-75295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SP3

Protein Name

Sp3 transcription factor

Synonyms

SPR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000310301

InnateDB Gene

IDBG-75293 (SP3)

Protein Structure

UniProt Annotation

Function

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. {ECO:0000269PubMed:10391891, ECO:0000269PubMed:11812829, ECO:0000269PubMed:12419227, ECO:0000269PubMed:12837748, ECO:0000269PubMed:15247228, ECO:0000269PubMed:15494207, ECO:0000269PubMed:15554904, ECO:0000269PubMed:16781829, ECO:0000269PubMed:17548428, ECO:0000269PubMed:18187045, ECO:0000269PubMed:18617891, ECO:0000269PubMed:9278495}.

Subcellular Localization

Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	34 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001503	ossification
GO:0001701	in utero embryonic development
GO:0001779	natural killer cell differentiation
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030224	monocyte differentiation
GO:0030324	lung development
GO:0030851	granulocyte differentiation
GO:0043353	enucleate erythrocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060216	definitive hemopoiesis