InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OLA1

Summary

InnateDB Protein

IDBP-75324.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OLA1

Protein Name

Obg-like ATPase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284719

InnateDB Gene

IDBG-75322 (OLA1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03167, ECO:0000269PubMed:20053727}. Nucleus {ECO:0000255HAMAP- Rule:MF_03167, ECO:0000269PubMed:20053727}. Nucleus, nucleolus {ECO:0000255HAMAP-Rule:MF_03167, ECO:0000269PubMed:20053727}. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0016887	ATPase activity
GO:0043022	ribosome binding
GO:0043023	ribosomal large subunit binding
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0015684	ferrous iron transport

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1
IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR012676 TGS-like
IPR013029 Domain of unknown function DUF933
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926
PF02421
PF06071

PRINTS

PR00326

PIRSF

PIRSF006641

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt