Version 5.4
Homo sapiens Protein: ESRP2
Summary
InnateDB Protein IDBP-753689.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESRP2
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000454554
InnateDB Gene IDBG-38166 (ESRP2)
Protein Structure
UniProt Annotation
Function mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269PubMed:19285943}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19285943}.
Disease Associations
Tissue Specificity Epithelial cell-specific. {ECO:0000269PubMed:19285943}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003729 mRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR012337 Ribonuclease H-like domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H6T0
PhosphoSite PhosphoSite-Q9H6T0
TrEMBL J3QQJ9
UniProt Splice Variant
Entrez Gene 80004
UniGene Hs.592053
RefSeq
HUGO HGNC:26152
OMIM 612960
CCDS
HPRD 07971
IMGT
EMBL AC020978 AF289577 AK025571 AK025901 BC030146
GenPept AAH30146 AAL55761 BAB15173 BAB15275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca