Homo sapiens Protein: DNASE1L2 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-754690.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | DNASE1L2 | ||||||||||
Protein Name | |||||||||||
Synonyms | DNAS1L2; | ||||||||||
Species | Homo sapiens | ||||||||||
Ensembl Protein | ENSP00000455358 | ||||||||||
InnateDB Gene | IDBG-10244 (DNASE1L2) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells. {ECO:0000269PubMed:16902420}. | ||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:16902420}. Secreted {ECO:0000305}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Preferentially expressed in the skin and up- regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum. {ECO:0000269PubMed:16902420}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | |||||||||||
InterPro |
IPR005135
Endonuclease/exonuclease/phosphatase IPR016202 Deoxyribonuclease I |
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PFAM |
PF03372
PF14529 |
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PRINTS |
PR00130
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PIRSF |
PIRSF000988
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SMART |
SM00476
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q92874 | ||||||||||
PhosphoSite | PhosphoSite-Q92874 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 1775 | ||||||||||
UniGene | Hs.103503 | ||||||||||
RefSeq | XP_005255209 | ||||||||||
HUGO | HGNC:2958 | ||||||||||
OMIM | 602622 | ||||||||||
CCDS | CCDS42105 | ||||||||||
HPRD | 04018 | ||||||||||
IMGT | |||||||||||
EMBL | AC009065 AK098028 AY298957 AY298958 BC035205 BC063710 CH471112 U62647 | ||||||||||
GenPept | AAB63981 AAH35205 AAH63710 AAQ73759 AAQ73760 AAQ73761 BAG53566 EAW85526 EAW85527 EAW85528 EAW85529 | ||||||||||