InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM40

Summary

InnateDB Protein

IDBP-75729.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM40

Protein Name

tripartite motif containing 40

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365914

InnateDB Gene

IDBG-75727 (TRIM40)

Protein Structure

UniProt Annotation

Function

May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity. {ECO:0000269PubMed:21474709}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract. {ECO:0000269PubMed:21474709}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0042177	negative regulation of protein catabolic process
GO:0045116	protein neddylation
GO:1900181	negative regulation of protein localization to nucleus
GO:1901223	negative regulation of NIK/NF-kappaB signaling