InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRPR

Summary

InnateDB Protein

IDBP-75771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRPR

Protein Name

signal recognition particle receptor (docking protein)

Synonyms

DP; Sralpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000328023

InnateDB Gene

IDBG-75769 (SRPR)

Protein Structure

UniProt Annotation

Function

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	11 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005047	signal recognition particle binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006613	cotranslational protein targeting to membrane
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0010467	gene expression
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005785	signal recognition particle receptor complex
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR003593 AAA+ ATPase domain
IPR005129 ArgK protein
IPR007222 Signal recognition particle receptor, alpha subunit, N-terminal
IPR011012 Longin-like domain
IPR013822 Signal recognition particle, SRP54 subunit, helical bundle
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00448
PF01656
PF03308
PF04086
PF02881

PRINTS

PIRSF

SMART

SM00962
SM00382
SM00963

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08240