Version 5.4
Homo sapiens Protein: FOXRED1
Summary
InnateDB Protein IDBP-75783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXRED1
Protein Name FAD-dependent oxidoreductase domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263578
InnateDB Gene IDBG-75781 (FOXRED1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. {ECO:0000269PubMed:20818383}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
Biological Process
GO:0008150 biological_process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006076 FAD dependent oxidoreductase
PFAM PF01266
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CU9
PhosphoSite PhosphoSite-Q96CU9
TrEMBL B4DXM1
UniProt Splice Variant
Entrez Gene 55572
UniGene Hs.317190
RefSeq NP_060017
HUGO HGNC:26927
OMIM 613622
CCDS CCDS8471
HPRD 13620
IMGT
EMBL AF103801 AF447877 AK023987 AK295267 AK298807 AK302039 AL136923 AP001318 BC002910 BC013902 CH471065
GenPept AAF02421 AAH02910 AAH13902 AAQ04652 BAG51246 BAG58254 BAG60942 BAG63433 CAB66857 EAW67683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca