Version 5.4
Homo sapiens Protein: LRRTM3
Summary
InnateDB Protein IDBP-75791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRTM3
Protein Name leucine rich repeat transmembrane neuronal 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355187
InnateDB Gene IDBG-75787 (LRRTM3)
Protein Structure
UniProt Annotation
Function Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in neuronal tissues. {ECO:0000269PubMed:12676565}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:1902004 positive regulation of beta-amyloid formation
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01462
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00013
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86VH5
PhosphoSite PhosphoSite-Q86VH5
TrEMBL B4DFC3
UniProt Splice Variant
Entrez Gene 347731
UniGene Hs.652155
RefSeq NP_821079
HUGO HGNC:19410
OMIM 610869
CCDS CCDS7270
HPRD 14324
IMGT
EMBL AK290168 AK294029 AY182028 AY358315 BC111492 BC113715 BC113717 BX640611
GenPept AAI11493 AAI13716 AAI13718 AAO67549 AAQ88681 BAF82857 BAG57384 CAE45717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca