InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCPS

Summary

InnateDB Protein

IDBP-75833.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCPS

Protein Name

decapping enzyme, scavenger

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263579

InnateDB Gene

IDBG-75831 (DCPS)

Protein Structure

UniProt Annotation

Function

Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre- mRNAs. Inhibits activation-induced cell death. {ECO:0000269PubMed:11747811, ECO:0000269PubMed:12198172, ECO:0000269PubMed:12871939, ECO:0000269PubMed:14523240, ECO:0000269PubMed:15273322, ECO:0000269PubMed:15383679, ECO:0000269PubMed:15769464, ECO:0000269PubMed:16140270, ECO:0000269PubMed:18426921, ECO:0000269PubMed:22985415}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.

Disease Associations

Tissue Specificity

Detected in liver, brain, kidney, testis and prostate. {ECO:0000269PubMed:12871939}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000340	RNA 7-methylguanosine cap binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0050072	m7G(5')pppN diphosphatase activity

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0036245	cellular response to menadione
GO:0043069	negative regulation of programmed cell death
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045292	mRNA cis splicing, via spliceosome