InnateDB Protein
|
IDBP-758731.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MSI2
|
Protein Name
|
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000462264
|
InnateDB Gene
|
IDBG-60416 (MSI2)
|
Protein Structure
|
|
Function |
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.
|
Disease Associations |
Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
|
Tissue Specificity |
Ubiquitous; detected at low levels. {ECO:0000269PubMed:12649177}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
14
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000504
RNA recognition motif domain
|
PFAM |
PF00076
|
PRINTS |
|
PIRSF |
|
SMART |
SM00360
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96DH6
|
PhosphoSite |
PhosphoSite-Q96DH6
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
124540
|
UniGene |
Hs.741833
|
RefSeq |
|
HUGO |
HGNC:18585
|
OMIM |
607897
|
CCDS |
|
HPRD |
07438
|
IMGT |
|
EMBL |
AK093888
BC001526
BC017560
|
GenPept |
AAH01526
AAH17560
BAC04244
|
|
|