InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELP5

Summary

InnateDB Protein

IDBP-758812.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELP5

Protein Name

Synonyms

C17orf81; DERP6; MST071; MSTP071;

Species

Homo sapiens

Ensembl Protein

ENSP00000459633

InnateDB Gene

IDBG-23995 (ELP5)

Protein Structure

UniProt Annotation

Function

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. {ECO:0000250, ECO:0000269PubMed:16850183}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030335	positive regulation of cell migration