Version 5.4
Homo sapiens Protein: AKAP1
Summary
InnateDB Protein IDBP-759543.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP1
Protein Name
Synonyms AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1; PPP1R43; PRKA1; SAKAP84; TDRD17;
Species Homo sapiens
Ensembl Protein ENSP00000459895
InnateDB Gene IDBG-60341 (AKAP1)
Protein Structure
UniProt Annotation
Function Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Subcellular Localization Mitochondrion outer membrane {ECO:0000305}.
Disease Associations
Tissue Specificity AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007596 blood coagulation
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002999 Tudor domain
IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
PFAM PF00567
PF00013
PF13014
PRINTS
PIRSF
SMART SM00333
SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92667
PhosphoSite PhosphoSite-Q92667
TrEMBL I3L3L9
UniProt Splice Variant
Entrez Gene 8165
UniGene Hs.690812
RefSeq
HUGO HGNC:367
OMIM 602449
CCDS CCDS11594
HPRD 03905
IMGT
EMBL AC007114 AK292416 BC000729 CH471109 U34074 X97335
GenPept AAC50279 AAH00729 BAF85105 CAA66000 EAW94515 EAW94516 EAW94518

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca