Version 5.4
Homo sapiens Protein: TOP3A
Summary
InnateDB Protein IDBP-760002.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP3A
Protein Name
Synonyms TOP3; ZGRF7;
Species Homo sapiens
Ensembl Protein ENSP00000466641
InnateDB Gene IDBG-33849 (TOP3A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR013497 DNA topoisomerase, type IA, central
IPR023405 DNA topoisomerase, type IA, core domain
PFAM PF01131
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 7156
UniGene Hs.592115
RefSeq
HUGO HGNC:11992
OMIM 601243
CCDS
HPRD 03145
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca