InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BARX2

Summary

InnateDB Protein

IDBP-76048.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BARX2

Protein Name

BARX homeobox 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000281437

InnateDB Gene

IDBG-76046 (BARX2)

Protein Structure

UniProt Annotation

Function

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001502	cartilage condensation
GO:0006351	transcription, DNA-templated
GO:0014902	myotube differentiation
GO:0042637	catagen
GO:0045944	positive regulation of transcription from RNA polymerase II promoter