InnateDB Protein
|
IDBP-761.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TWSG1
|
Protein Name
|
twisted gastrulation homolog 1 (Drosophila)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000262120
|
InnateDB Gene
|
IDBG-759 (TWSG1)
|
Protein Structure
|
|
Function |
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Secreted {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR006761
Twisted gastrulation (Tsg) protein
|
PFAM |
PF04668
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9GZX9
|
PhosphoSite |
PhosphoSite-Q9GZX9
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
57045
|
UniGene |
Hs.603728
|
RefSeq |
NP_065699
|
HUGO |
HGNC:12429
|
OMIM |
605049
|
CCDS |
CCDS11844
|
HPRD |
05443
|
IMGT |
|
EMBL |
AF196834
AF294628
AJ297391
AK027629
AK075550
AK315751
AP001033
BC020490
CH471113
|
GenPept |
AAG10076
AAG43468
AAH20490
BAB55246
BAC11693
BAG38105
CAC05581
EAX01606
EAX01607
|
|
|