InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UPF1

Summary

InnateDB Protein

IDBP-761048.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPF1

Protein Name

Synonyms

HUPF1; NORF1; pNORF1; RENT1; smg-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000470142

InnateDB Gene

IDBG-38885 (UPF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 155 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	155 [view]
Protein-Protein	153 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006406	mRNA export from nucleus
GO:0006449	regulation of translational termination
GO:0009048	dosage compensation by inactivation of X chromosome
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0071044	histone mRNA catabolic process

Cellular Component

GO:0000785	chromatin
GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0035145	exon-exon junction complex
GO:0044530	supraspliceosomal complex