Version 5.4
Homo sapiens Protein: PLXDC1
Summary
InnateDB Protein IDBP-761163.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXDC1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000462089
InnateDB Gene IDBG-45218 (PLXDC1)
Protein Structure
UniProt Annotation
Function Plays a critical role in endothelial cell capillary morphogenesis. {ECO:0000250}.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. {ECO:0000269PubMed:10947988, ECO:0000269PubMed:11559528, ECO:0000269PubMed:17560052, ECO:0000269PubMed:18316703}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0007275 multicellular organismal development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR016201 Plexin-like fold
PFAM
PRINTS
PIRSF
SMART SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUK5
PhosphoSite PhosphoSite-Q8IUK5
TrEMBL J3QR40
UniProt Splice Variant
Entrez Gene 57125
UniGene Hs.739581
RefSeq
HUGO HGNC:20945
OMIM 606826
CCDS
HPRD 08439
IMGT
EMBL AC004408 AC091178 AF279144 AF378753 AK312999 AY704670 AY704671 AY704672 BC036059
GenPept AAG00869 AAH36059 AAL11990 AAV85657 AAV85658 AAV85659 BAG35835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca