InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RUVBL2

Summary

InnateDB Protein

IDBP-761175.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUVBL2

Protein Name

Synonyms

ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B;

Species

Homo sapiens

Ensembl Protein

ENSP00000473172

InnateDB Gene

IDBG-61221 (RUVBL2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	240 [view]
Protein-Protein	237 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003678	DNA helicase activity
GO:0003684	damaged DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0031490	chromatin DNA binding
GO:0042802	identical protein binding
GO:0043141	ATP-dependent 5'-3' DNA helicase activity
GO:0051082	unfolded protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006457	protein folding
GO:0032508	DNA duplex unwinding
GO:0034644	cellular response to UV
GO:0035066	positive regulation of histone acetylation
GO:0040008	regulation of growth
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071169	establishment of protein localization to chromatin
GO:0071392	cellular response to estradiol stimulus
GO:0071733	transcriptional activation by promoter-enhancer looping
GO:0071899	negative regulation of estrogen receptor binding

Cellular Component

GO:0000812	Swr1 complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005719	nuclear euchromatin
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030529	ribonucleoprotein complex
GO:0031011	Ino80 complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0070062	extracellular vesicular exosome
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR004504 DNA repair protein RadA
IPR007694 DNA helicase, DnaB-like, C-terminal
IPR010339 TIP49, C-terminal
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF03796
PF06068

PRINTS

PR01874

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt