InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP5M1

Summary

InnateDB Protein

IDBP-7616.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP5M1

Protein Name

MU-2/AP1M2 domain containing, death-inducing

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261558

InnateDB Gene

IDBG-7614 (AP5M1)

Protein Structure

UniProt Annotation

Function

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death. {ECO:0000269PubMed:18395520, ECO:0000269PubMed:22022230}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:22022230}. Late endosome membrane {ECO:0000305PubMed:22022230}; Peripheral membrane protein {ECO:0000305PubMed:22022230}; Cytoplasmic side {ECO:0000305PubMed:22022230}. Lysosome membrane {ECO:0000305PubMed:22022230}; Peripheral membrane protein {ECO:0000305PubMed:22022230}; Cytoplasmic side {ECO:0000305PubMed:22022230}. Note=May cycle on and off membranes.

Disease Associations

Tissue Specificity

Expressed in various tumor cell lines including Jurkat, Hep-G2 and HeLa. {ECO:0000269PubMed:18395520}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport
GO:0016197	endosomal transport

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030119	AP-type membrane coat adaptor complex
GO:0030131	clathrin adaptor complex
GO:0031902	late endosome membrane