InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCAR1

Summary

InnateDB Protein

IDBP-76174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCAR1

Protein Name

cell division cycle and apoptosis regulator 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265872

InnateDB Gene

IDBG-76172 (CCAR1)

Protein Structure

UniProt Annotation

Function

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. {ECO:0000250, ECO:0000269PubMed:12816952}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:12816952}.

Disease Associations

Tissue Specificity

Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. {ECO:0000269PubMed:12816952}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0008380	RNA splicing
GO:0010467	gene expression