InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENDOV

Summary

InnateDB Protein

IDBP-761849.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENDOV

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000458391

InnateDB Gene

IDBG-71767 (ENDOV)

Protein Structure

UniProt Annotation

Function

Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures. {ECO:0000269PubMed:23139746, ECO:0000269PubMed:23912683, ECO:0000269PubMed:23912718}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003727	single-stranded RNA binding
GO:0004519	endonuclease activity
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
GO:0043566	structure-specific DNA binding