InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLD2

Summary

InnateDB Protein

IDBP-762179.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLD2

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000459571

InnateDB Gene

IDBG-19793 (PLD2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001683 Phox homologous domain
IPR001736 Phospholipase D/Transphosphatidylase
IPR001849 Pleckstrin homology domain
IPR016555 Phospholipase D, eukaryota

PFAM

PF00787
PF00614
PF00169

PRINTS

PIRSF

PIRSF009376

SMART

SM00312
SM00155
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt