InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G4C

Summary

InnateDB Protein

IDBP-762193.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G4C

Protein Name

Synonyms

CPLA2-gamma;

Species

Homo sapiens

Ensembl Protein

ENSP00000472546

InnateDB Gene

IDBG-59981 (PLA2G4C)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	2 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0005543	phospholipid binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006954	inflammatory response
GO:0007567	parturition
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0035556	intracellular signal transduction
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0046475	glycerophospholipid catabolic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002642 Lysophospholipase, catalytic domain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase

PFAM

PF01735

PRINTS

PIRSF

SMART

SM00022

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q9UP65

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB105806 AB105807 AB105808 AC010458 AC011466 AF058921 AF065214 AK295400 AK314524 AL050193 AY485310 BC063416 CH471177 CR456816

GenPept

AAC32823 AAC78835 AAH63416 AAR25453 BAC87744 BAC87745 BAC87746 BAG37118 BAG58352 CAB43312 CAG33097 EAW52314

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca