Version 5.4
Homo sapiens Protein: IPPK
Summary
InnateDB Protein IDBP-76253.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IPPK
Protein Name inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000287996
InnateDB Gene IDBG-76251 (IPPK)
Protein Structure
UniProt Annotation
Function Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269PubMed:12084730, ECO:0000269PubMed:15967797}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with high expression in heart, brain, testis and placenta. {ECO:0000269PubMed:12084730}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0035299 inositol pentakisphosphate 2-kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0052746 inositol phosphorylation
Cellular Component
GO:0005622 intracellular
GO:0005654 nucleoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR009286 Inositol-pentakisphosphate 2-kinase
PFAM PF06090
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H8X2
PhosphoSite PhosphoSite-Q9H8X2
TrEMBL X6R9A6
UniProt Splice Variant
Entrez Gene 64768
UniGene Hs.674179
RefSeq NP_073592
HUGO HGNC:14645
OMIM
CCDS CCDS6699
HPRD 10799
IMGT
EMBL AF351202 AF520811 AK023225 AK024267 AL137074 AL157827 BC026154
GenPept AAH26154 AAK69692 AAM75353 BAB14476 BAB14866 CAI12586 CAI12593 CAI14368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca