InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL12RB1

Summary

InnateDB Protein

IDBP-763347.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL12RB1

Protein Name

Synonyms

CD212; IL-12R-BETA1; IL12RB; IMD30;

Species

Homo sapiens

Ensembl Protein

ENSP00000470788

InnateDB Gene

IDBG-37559 (IL12RB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0016517	interleukin-12 receptor activity
GO:0019955	cytokine binding
GO:0042019	interleukin-23 binding
GO:0042020	interleukin-23 receptor activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002230	positive regulation of defense response to virus by host
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0007165	signal transduction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0032729	positive regulation of interferon-gamma production
GO:0035722	interleukin-12-mediated signaling pathway
GO:0038155	interleukin-23-mediated signaling pathway
GO:0042104	positive regulation of activated T cell proliferation
GO:0043382	positive regulation of memory T cell differentiation
GO:0071346	cellular response to interferon-gamma
GO:2000318	positive regulation of T-helper 17 type immune response
GO:2000330	positive regulation of T-helper 17 cell lineage commitment