InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LONP1

Summary

InnateDB Protein

IDBP-763631.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LONP1

Protein Name

Synonyms

hLON; LON; LonHS; LONP; PIM1; PRSS15;

Species

Homo sapiens

Ensembl Protein

ENSP00000468541

InnateDB Gene

IDBG-20471 (LONP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003727	single-stranded RNA binding
GO:0004176	ATP-dependent peptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0043531	ADP binding
GO:0043565	sequence-specific DNA binding
GO:0051880	G-quadruplex DNA binding
GO:0070182	DNA polymerase binding
GO:0070361	mitochondrial light strand promoter anti-sense binding
GO:0070362	mitochondrial heavy strand promoter anti-sense binding

Biological Process

GO:0000002	mitochondrial genome maintenance
GO:0001666	response to hypoxia
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006508	proteolysis
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0007005	mitochondrion organization
GO:0032042	mitochondrial DNA metabolic process
GO:0034599	cellular response to oxidative stress
GO:0051131	chaperone-mediated protein complex assembly
GO:0051260	protein homooligomerization
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0070407	oxidation-dependent protein catabolic process
GO:0090296	regulation of mitochondrial DNA replication

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

InterPro

IPR003111 Peptidase S16, lon N-terminal
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR004815 Lon protease, bacterial/eukaryotic-type
IPR008269 Peptidase S16, Lon C-terminal
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR013153 PrkA AAA domain
IPR015947 PUA-like domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM