Homo sapiens Protein: EIF5A | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-763835.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | EIF5A | ||||||||||||||||||||||
Protein Name | |||||||||||||||||||||||
Synonyms | EIF-5A; EIF5A1; eIF5AI; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000459196 | ||||||||||||||||||||||
InnateDB Gene | IDBG-24314 (EIF5A) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269PubMed:15371445, ECO:0000269PubMed:15452064, ECO:0000269PubMed:16987817, ECO:0000269PubMed:17187778, ECO:0000269PubMed:17360499}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). {ECO:0000269PubMed:16519677}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001884
Translation elongation factor IF5A IPR005824 KOW IPR008991 Translation protein SH3-like domain IPR012340 Nucleic acid-binding, OB-fold IPR020189 Translation elongation factor, IF5A C-terminal |
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PFAM |
PF00467
PF01287 |
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PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF003025
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SMART |
SM00739
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P63241 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P63241 | ||||||||||||||||||||||
TrEMBL | I3L397 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 1984 | ||||||||||||||||||||||
UniGene | Hs.523097 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:3300 | ||||||||||||||||||||||
OMIM | 600187 | ||||||||||||||||||||||
CCDS | CCDS11099 | ||||||||||||||||||||||
HPRD | 02555 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC026954 AK292615 AY129319 AY129320 AY129321 AY129322 BC000751 BC001832 BC030160 BC080196 BC085015 BC107779 CH471108 M23419 S72024 U17969 | ||||||||||||||||||||||
GenPept | AAA58453 AAA86989 AAD14095 AAH00751 AAH01832 AAH30160 AAH80196 AAH85015 AAI07780 AAN17514 AAN17515 AAN17516 AAN17518 BAF85304 EAW90219 EAW90220 EAW90221 EAW90222 | ||||||||||||||||||||||