Version 5.4
Homo sapiens Protein: MSL1
Summary
InnateDB Protein IDBP-763953.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSL1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000462945
InnateDB Gene IDBG-47197 (MSL1)
Protein Structure
UniProt Annotation
Function Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000269PubMed:16227571, ECO:0000269PubMed:21726816, ECO:0000269PubMed:22547026}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15561718}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006325 chromatin organization
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0072487 MSL complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q68DK7
PhosphoSite PhosphoSite-Q68DK7
TrEMBL B4DMT3
UniProt Splice Variant
Entrez Gene 339287
UniGene
RefSeq NP_001012241
HUGO HGNC:27905
OMIM 614801
CCDS CCDS45670
HPRD
IMGT
EMBL AC068669 AK125654 AK297619 AL049450 BC118997 BC122543 CR749360
GenPept AAI18998 AAI22544 BAG54229 BAG59995 CAH10734 CAH18213

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca