InnateDB Protein
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IDBP-764108.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CENPV
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000462377
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InnateDB Gene
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IDBG-32142 (CENPV)
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Protein Structure
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Function |
Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. {ECO:0000269PubMed:18772885}.
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Subcellular Localization |
Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006913
Glutathione-dependent formaldehyde-activating enzyme/centromere protein V
IPR011057
Mss4-like
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PFAM |
PF04828
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z7K6
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PhosphoSite |
PhosphoSite-Q7Z7K6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
201161
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UniGene |
Hs.677906
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RefSeq |
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HUGO |
HGNC:29920
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OMIM |
608139
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF514992
AY382899
BC052604
BC137486
BC137487
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GenPept |
AAH52604
AAI37487
AAI37488
AAM76703
AAR24368
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