Homo sapiens Protein: TOP3A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-764356.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | TOP3A | ||||||||||||||||||
Protein Name | |||||||||||||||||||
Synonyms | TOP3; ZGRF7; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000462790 | ||||||||||||||||||
InnateDB Gene | IDBG-33849 (TOP3A) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. {ECO:0000269PubMed:20445207, ECO:0000269PubMed:8622991}. | ||||||||||||||||||
Subcellular Localization | |||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | High expression is found in testis, heart, skeletal muscle and pancreas. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000380
DNA topoisomerase, type IA IPR001878 Zinc finger, CCHC-type IPR003601 DNA topoisomerase, type IA, domain 2 IPR003602 DNA topoisomerase, type IA, DNA-binding domain IPR006171 Toprim domain IPR010666 Zinc finger, GRF-type IPR013497 DNA topoisomerase, type IA, central IPR013498 DNA topoisomerase, type IA, zn finger IPR023405 DNA topoisomerase, type IA, core domain |
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PFAM |
PF00098
PF01751 PF13662 PF06839 PF01131 PF01396 |
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PRINTS |
PR00417
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PIRSF | |||||||||||||||||||
SMART |
SM00343
SM00436 SM00437 SM00493 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q13472 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q13472 | ||||||||||||||||||
TrEMBL | B4DSJ0 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 7156 | ||||||||||||||||||
UniGene | Hs.592115 | ||||||||||||||||||
RefSeq | XP_005256833 | ||||||||||||||||||
HUGO | HGNC:11992 | ||||||||||||||||||
OMIM | 601243 | ||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | 03145 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC127537 AK126869 AK290513 AK292926 AK296437 AK299764 BC051748 CH471196 HQ205026 HQ205027 HQ205028 HQ205029 HQ205030 HQ205031 HQ205032 HQ205033 HQ205034 HQ205035 HQ205036 HQ205037 HQ205038 HQ205039 HQ205040 HQ205041 HQ205042 HQ205043 HQ205044 HQ205045 HQ205046 HQ205047 HQ205048 HQ205049 HQ205050 HQ205051 HQ205052 HQ205053 HQ205054 HQ205055 HQ205056 HQ205057 HQ205058 HQ205059 HQ205060 HQ205061 HQ205062 HQ205063 HQ205064 HQ205065 U43431 | ||||||||||||||||||
GenPept | AAB03694 AAB03695 AAH51748 ADP90454 ADP90455 ADP90456 ADP90457 ADP90458 ADP90459 ADP90460 ADP90461 ADP90462 ADP90463 ADP90464 ADP90465 ADP90466 ADP90467 ADP90468 ADP90469 ADP90470 ADP90471 ADP90472 ADP90473 ADP90474 ADP90475 ADP90476 ADP90477 ADP90478 ADP90479 ADP90480 ADP90481 ADP90482 ADP90483 ADP90484 ADP90485 ADP90486 ADP90487 ADP90488 ADP90489 ADP90490 ADP90491 ADP90492 ADP90493 BAF83202 BAF85615 BAG54385 BAG59092 BAG61652 EAW55646 EAW55648 EAW55649 | ||||||||||||||||||