Version 5.4
Homo sapiens Protein: GPR77
Summary
InnateDB Protein IDBP-764384.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR77
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000471184
InnateDB Gene IDBG-59470 (GPR77)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004944 C5a anaphylatoxin receptor activity
GO:0005515 protein binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032720 negative regulation of tumor necrosis factor production
GO:0045087 innate immune response (InnateDB)
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090024 negative regulation of neutrophil chemotaxis
GO:1900165 negative regulation of interleukin-6 secretion
GO:2000482 regulation of interleukin-8 secretion
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016021 integral component of membrane
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001274 C5a1/C5a2 anaphylatoxin chemotactic receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR00426
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P296
PhosphoSite PhosphoSite-Q9P296
TrEMBL
UniProt Splice Variant
Entrez Gene 27202
UniGene Hs.534412
RefSeq NP_060955
HUGO HGNC:4527
OMIM 609949
CCDS CCDS12699
HPRD 17072
IMGT
EMBL AB038237 AC008754 AF317655 AK313994 AY268430 BC067478 CH471126
GenPept AAH67478 AAK12640 AAP23197 BAA95414 BAG36706 EAW57472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca