InnateDB Protein
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IDBP-76458.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATAT1
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Protein Name
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alpha tubulin acetyltransferase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000324459
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InnateDB Gene
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IDBG-76456 (ATAT1)
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Protein Structure
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Function |
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:20829795, ECO:0000269PubMed:21068373, ECO:0000269PubMed:24097348}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:24097348}. Membrane, clathrin-coated pit {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:24097348}. Cell junction, focal adhesion {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:24097348}. Cell projection, axon {ECO:0000255HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton {ECO:0000255HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton, spindle {ECO:0000255HAMAP-Rule:MF_03130}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0019799
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tubulin N-acetyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007965
Alpha-tubulin N-acetyltransferase
IPR016181
Acyl-CoA N-acyltransferase
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PFAM |
PF05301
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5SQI0
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PhosphoSite |
PhosphoSite-Q5SQI0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79969
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UniGene |
Hs.654798
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RefSeq |
NP_001241881
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HUGO |
HGNC:21186
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OMIM |
615556
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CCDS |
CCDS59002
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HPRD |
12850
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IMGT |
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EMBL |
AB075512
AK023220
AL662800
AL732442
AL833858
AL845353
BC006105
BC047303
BX119957
BX908728
CH471081
CR753328
CR759778
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GenPept |
AAH06105
AAH47303
BAB14472
BAE45758
CAD38717
CAI17752
CAI17753
CAI17754
CAI17755
CAI18164
CAI18165
CAI18166
CAI18167
CAI18168
CAI41870
CAI41871
CAI41872
CAI41873
CAI41874
CAI41875
CAM25005
CAM25006
CAM25498
CAM25912
CAM25913
CAM25914
CAM25915
CAM25916
CAM25917
CAP58454
CAP58455
CAP58456
CAP58457
CAP58458
CAP58459
CAQ07413
CAQ07414
CAQ07415
CAQ07416
CAQ07417
CAQ07418
CAQ09406
CAQ09407
CAQ09408
CAQ09409
CAQ09410
CAQ09411
EAX03306
EAX03307
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