InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATAT1

Summary

InnateDB Protein

IDBP-76464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATAT1

Protein Name

alpha tubulin acetyltransferase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324222

InnateDB Gene

IDBG-76456 (ATAT1)

Protein Structure

UniProt Annotation

Function

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:20829795, ECO:0000269PubMed:21068373, ECO:0000269PubMed:24097348}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:24097348}. Membrane, clathrin-coated pit {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:24097348}. Cell junction, focal adhesion {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:24097348}. Cell projection, axon {ECO:0000255HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton {ECO:0000255HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton, spindle {ECO:0000255HAMAP-Rule:MF_03130}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019799	tubulin N-acetyltransferase activity

Biological Process

GO:0048666	neuron development
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0071929	alpha-tubulin acetylation

Cellular Component

GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005905	coated pit
GO:0005925	focal adhesion
GO:0030424	axon

Protein Structure and Domains

PDB ID

InterPro

IPR007965 Alpha-tubulin N-acetyltransferase
IPR016181 Acyl-CoA N-acyltransferase

PFAM

PF05301

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5SQI0

PhosphoSite

PhosphoSite-Q5SQI0

TrEMBL

UniProt Splice Variant

Entrez Gene

79969

UniGene

Hs.654798

RefSeq

XP_005249477

HUGO

HGNC:21186

OMIM

615556

CCDS

HPRD

12850

IMGT

EMBL

AB075512 AK023220 AL662800 AL732442 AL833858 AL845353 BC006105 BC047303 BX119957 BX908728 CH471081 CR753328 CR759778

GenPept

AAH06105 AAH47303 BAB14472 BAE45758 CAD38717 CAI17752 CAI17753 CAI17754 CAI17755 CAI18164 CAI18165 CAI18166 CAI18167 CAI18168 CAI41870 CAI41871 CAI41872 CAI41873 CAI41874 CAI41875 CAM25005 CAM25006 CAM25498 CAM25912 CAM25913 CAM25914 CAM25915 CAM25916 CAM25917 CAP58454 CAP58455 CAP58456 CAP58457 CAP58458 CAP58459 CAQ07413 CAQ07414 CAQ07415 CAQ07416 CAQ07417 CAQ07418 CAQ09406 CAQ09407 CAQ09408 CAQ09409 CAQ09410 CAQ09411 EAX03306 EAX03307