InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFP36

Summary

InnateDB Protein

IDBP-764642.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFP36

Protein Name

Synonyms

G0S24; GOS24; NUP475; RNF162A; TIS11; TTP; zfp-36;

Species

Homo sapiens

Ensembl Protein

ENSP00000469647

InnateDB Gene

IDBG-50307 (ZFP36)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	48 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003727	single-stranded RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0019901	protein kinase binding
GO:0019957	C-C chemokine binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006402	mRNA catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0032680	regulation of tumor necrosis factor production
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0035556	intracellular signal transduction
GO:0042594	response to starvation
GO:0043488	regulation of mRNA stability
GO:0045638	negative regulation of myeloid cell differentiation
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay