InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STRA13

Summary

InnateDB Protein

IDBP-764962.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STRA13

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000462015

InnateDB Gene

IDBG-73033 (STRA13)

Protein Structure

UniProt Annotation

Function

DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. {ECO:0000269PubMed:19620631, ECO:0000269Ref.5, ECO:0000269Ref.6}.

Subcellular Localization

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0006281	DNA repair
GO:0007067	mitotic nuclear division
GO:0031297	replication fork processing
GO:0031398	positive regulation of protein ubiquitination
GO:0051382	kinetochore assembly