InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCA7

Summary

InnateDB Protein

IDBP-765184.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA7

Protein Name

Synonyms

ABCA-SSN; ABCX;

Species

Homo sapiens

Ensembl Protein

ENSP00000465322

InnateDB Gene

IDBG-13665 (ABCA7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0034188	apolipoprotein A-I receptor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006909	phagocytosis
GO:0007613	memory
GO:0010875	positive regulation of cholesterol efflux
GO:0017121	phospholipid scrambling
GO:0018149	peptide cross-linking
GO:0032780	negative regulation of ATPase activity
GO:0032781	positive regulation of ATPase activity
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034380	high-density lipoprotein particle assembly
GO:0034504	protein localization to nucleus
GO:0038027	apolipoprotein A-I-mediated signaling pathway
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0050766	positive regulation of phagocytosis
GO:0055085	transmembrane transport
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1900223	positive regulation of beta-amyloid clearance
GO:1901076	positive regulation of engulfment of apoptotic cell
GO:1902430	negative regulation of beta-amyloid formation
GO:1902995	positive regulation of phospholipid efflux

Cellular Component

GO:0000139	Golgi membrane
GO:0001891	phagocytic cup
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0032587	ruffle membrane
GO:0043190	ATP-binding cassette (ABC) transporter complex

Protein Structure and Domains

PDB ID

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011032 GroES (chaperonin 10)-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IZY2