Version 5.4
Homo sapiens Protein: KLK3
Summary
InnateDB Protein IDBP-765264.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK3
Protein Name
Synonyms APS; hK3; KLK2A1; PSA;
Species Homo sapiens
Ensembl Protein ENSP00000472907
InnateDB Gene IDBG-64971 (KLK3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 9 [view]
Protein-DNA 25 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016525 negative regulation of angiogenesis
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07288
PhosphoSite PhosphoSite-P07288
TrEMBL
UniProt Splice Variant
Entrez Gene 354
UniGene Hs.600536
RefSeq
HUGO HGNC:6364
OMIM 176820
CCDS
HPRD 01461
IMGT
EMBL AC011523 AF243527 AJ512346 BC005307 BC050595 BC056665 BF679511 BQ932072 BT019862 CH471135 M21896 M24543 M26663 M27274 S75755 U17040 X05332 X07730 X13940 X13941 X13942 X13943 X13944 X14810
GenPept AAA56764 AAA58802 AAA59996 AAA60192 AAA60193 AAD14185 AAG33355 AAH05307 AAH50595 AAH56665 AAV38665 CAA28947 CAA32123 CAA32124 CAA32126 CAA32127 CAA32915 CAB46487 CAD54617 EAW71929 EAW71930 EAW71936

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca