InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELANE

Summary

InnateDB Protein

IDBP-765684.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELANE

Protein Name

Synonyms

ELA2; GE; HLE; HNE; NE; PMN-E; SCN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000466090

InnateDB Gene

IDBG-13111 (ELANE)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	51 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0002020	protease binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0019955	cytokine binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001878	response to yeast
GO:0002438	acute inflammatory response to antigenic stimulus
GO:0006508	proteolysis
GO:0006874	cellular calcium ion homeostasis
GO:0006909	phagocytosis
GO:0009411	response to UV
GO:0022617	extracellular matrix disassembly
GO:0030163	protein catabolic process
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0032496	response to lipopolysaccharide
GO:0042742	defense response to bacterium
GO:0043406	positive regulation of MAP kinase activity
GO:0044130	negative regulation of growth of symbiont in host
GO:0045079	negative regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050778	positive regulation of immune response
GO:0050832	defense response to fungus
GO:0050900	leukocyte migration
GO:0050922	negative regulation of chemotaxis
GO:0070947	neutrophil mediated killing of fungus

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0017053	transcriptional repressor complex
GO:0030141	secretory granule
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt