InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX16

Summary

InnateDB Protein

IDBP-76571.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX16

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 16

Synonyms

DBP2; DDX16; PRO2014; Prp2; PRP8; PRPF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000365625

InnateDB Gene

IDBG-76569 (DHX16)

Protein Structure

UniProt Annotation

Function

Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60231