InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNA1A

Summary

InnateDB Protein

IDBP-765921.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1A

Protein Name

Synonyms

APCA; BI; CACNL1A4; CAV2.1; EA2; FHM; HPCA; MHP; MHP1; SCA6;

Species

Homo sapiens

Ensembl Protein

ENSP00000460092

InnateDB Gene

IDBG-31996 (CACNA1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	106 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0019905	syntaxin binding
GO:0046872	metal ion binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission
GO:0008219	cell death
GO:0034765	regulation of ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0051899	membrane depolarization
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005448 Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01632

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt