InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMARCA4

Summary

InnateDB Protein

IDBP-766019.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCA4

Protein Name

Synonyms

BAF190; BAF190A; BRG1; hSNF2b; MRD16; RTPS2; SNF2; SNF2L4; SNF2LB; SWI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000464778

InnateDB Gene

IDBG-28592 (SMARCA4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 331 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	331 [view]
Protein-Protein	305 [view]
Protein-DNA	24 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0030957	Tat protein binding
GO:0031492	nucleosomal DNA binding
GO:0047485	protein N-terminus binding
GO:0050681	androgen receptor binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003407	neural retina development
GO:0006200	ATP catabolic process
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007070	negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0030308	negative regulation of cell growth
GO:0043044	ATP-dependent chromatin remodeling
GO:0043923	positive regulation by host of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000790	nuclear chromatin
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane
GO:0016514	SWI/SNF complex
GO:0043234	protein complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001487 Bromodomain
IPR001650 Helicase, C-terminal
IPR006576 BRK domain
IPR013999 HAS subgroup
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014012 Helicase/SANT-associated, DNA binding
IPR014978 Glutamine-Leucine-Glutamine, QLQ
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00439
PF00271
PF07533
PF07529
PF08880

PRINTS

PR00503

PIRSF

SMART

SM00297
SM00490
SM00592
SM00573
SM00487
SM00951

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt