Version 5.4
Homo sapiens Protein: SERINC3
Summary
InnateDB Protein IDBP-76683.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERINC3
Protein Name serine incorporator 3
Synonyms AIGP1; DIFF33; SBBI99; TDE; TDE1; TMS-1;
Species Homo sapiens
Ensembl Protein ENSP00000340243
InnateDB Gene IDBG-76679 (SERINC3)
Protein Structure
UniProt Annotation
Function May be involved in cellular transformation.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:1902237 positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005016 Serine incorporator/TMS membrane protein
PFAM PF03348
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13530
PhosphoSite PhosphoSite-Q13530
TrEMBL Q5H936
UniProt Splice Variant
Entrez Gene 10955
UniGene Hs.696043
RefSeq NP_006802
HUGO HGNC:11699
OMIM 607165
CCDS CCDS13333
HPRD 06201
IMGT
EMBL AF112227 AF153979 AK300618 BC006088 U49188 Z97053
GenPept AAB48858 AAD22448 AAD34641 AAH06088 BAG62311 CAB09783

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca