Version 5.4
Homo sapiens Protein: FAM120A
Summary
InnateDB Protein IDBP-76697.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM120A
Protein Name family with sequence similarity 120A
Synonyms C9orf10; DNAPTP1; DNAPTP5; OSSA;
Species Homo sapiens
Ensembl Protein ENSP00000364538
InnateDB Gene IDBG-76689 (FAM120A)
Protein Structure
UniProt Annotation
Function May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous- type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. {ECO:0000250, ECO:0000269PubMed:19015244}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19015244}. Cell membrane {ECO:0000269PubMed:19015244}; Peripheral membrane protein {ECO:0000269PubMed:19015244}; Cytoplasmic side {ECO:0000269PubMed:19015244}. Note=Translocates to plasma membrane upon ultraviolet exposure.
Disease Associations
Tissue Specificity Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level). {ECO:0000269PubMed:14585507, ECO:0000269PubMed:19015244}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR029060 PIN domain-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZB2
PhosphoSite PhosphoSite-Q9NZB2
TrEMBL
UniProt Splice Variant
Entrez Gene 23196
UniGene Hs.670381
RefSeq NP_001273653
HUGO HGNC:13247
OMIM 612265
CCDS CCDS75859
HPRD 12928
IMGT
EMBL AF055017 AF214737 AF214738 AL353629 AY266457 BC007879 BC098584 BC111736 D80005
GenPept AAC09364 AAF72866 AAF72867 AAH07879 AAH98584 AAI11737 AAP31031 BAA11500 CAI96105 CAI96106 CAI96108 CAI96109

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca