InnateDB Protein
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IDBP-76848.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IER3
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Protein Name
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immediate early response 3
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Synonyms
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DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1; PRG1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000259874
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InnateDB Gene
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IDBG-76842 (IER3)
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Protein Structure
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Function |
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. {ECO:0000269PubMed:12356731, ECO:0000269PubMed:16456541, ECO:0000269PubMed:22565310}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:12356731}; Single-pass type II membrane protein {ECO:0000269PubMed:12356731}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001562
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response to protozoan
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GO:0003085
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negative regulation of systemic arterial blood pressure
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GO:0006282
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regulation of DNA repair
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GO:0006915
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apoptotic process
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GO:0007095
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mitotic G2 DNA damage checkpoint
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GO:0008630
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intrinsic apoptotic signaling pathway in response to DNA damage
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GO:0009653
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anatomical structure morphogenesis
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GO:0043066
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negative regulation of apoptotic process
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GO:0045732
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positive regulation of protein catabolic process
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GO:0045820
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negative regulation of glycolytic process
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GO:0046822
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regulation of nucleocytoplasmic transport
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GO:0050728
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negative regulation of inflammatory response
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GO:1901029
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negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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GO:2000377
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regulation of reactive oxygen species metabolic process
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GO:2001020
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regulation of response to DNA damage stimulus
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P46695
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PhosphoSite |
PhosphoSite-P46695
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8870
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UniGene |
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RefSeq |
NP_003888
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HUGO |
HGNC:5392
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OMIM |
602996
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CCDS |
CCDS4689
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HPRD |
04295
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IMGT |
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EMBL |
AL662797
BA000025
BC000844
BC005080
BT006703
S81914
X96438
Y14551
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GenPept |
AAB36278
AAH00844
AAH05080
AAP35349
BAB63319
CAA65304
CAA74886
CAI18210
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