Homo sapiens Protein: WISP2
Summary
InnateDB Protein IDBP-76870.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WISP2
Protein Name WNT1 inducible signaling pathway protein 2
Synonyms CCN5; CT58; CTGF-L;
Species Homo sapiens
Ensembl Protein ENSP00000190983
InnateDB Gene IDBG-76864 (WISP2)
Protein Structure
UniProt Annotation
Function May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
PFAM PF00219
PF00090
PF00093
PRINTS
PIRSF
SMART SM00121
SM00209
SM00214
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O76076
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 8839
UniGene Hs.592145
RefSeq NP_003872
HUGO HGNC:12770
OMIM 603399
CCDS CCDS13336
HPRD 16020
IMGT
EMBL AF074604 AF083500 AF100780 AK313853 AL139352 AY358915 BC017782 BC064379 CH471077
GenPept AAC26794 AAC70350 AAC96322 AAH17782 AAH64379 AAQ89274 BAG36581 CAB94788 EAW75902 EAW75903