InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FSCN1

Summary

InnateDB Protein

IDBP-7695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FSCN1

Protein Name

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

Synonyms

FAN1; HSN; p55; SNL;

Species

Homo sapiens

Ensembl Protein

ENSP00000371798

InnateDB Gene

IDBG-7693 (FSCN1)

Protein Structure

UniProt Annotation

Function

Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. {ECO:0000269PubMed:20137952, ECO:0000269PubMed:20393565, ECO:0000269PubMed:9362073, ECO:0000269PubMed:9571235}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0008283	cell proliferation
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0048870	cell motility
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0030175	filopodium
GO:0070062	extracellular vesicular exosome
GO:0071437	invadopodium